A theoretical study of the initiation, maintenance and termination of gastric slow wave re-entry.

ABSTRACT:

Unlabelled

Gastric slow wave dysrhythmias are associated with motility disorders. Periods of tachygastria associated with slow wave re-entry were recently recognized as one important dysrhythmia mechanism, but factors promoting and sustaining gastric re-entry are currently unknown. This study reports two experimental forms of gastric re-entry and presents a series of multi-scale models that define criteria for slow wave re-entry initiation, maintenance and termination. High-resolution electrical mapping was conducted in porcine and canine models and two spatiotemporal patterns of re-entrant activities were captured: single-loop rotor and double-loop figure-of-eight. Two separate multi-scale mathematical models were developed to reproduce the velocity and entrainment frequency of th

SUBMITTER: Du P 

PROVIDER: S-EPMC4486628 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature