BRAF gene: From human cancers to developmental syndromes.

ABSTRACT: The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better understand its parallel involvement in both tumourigenesis and RAS/MAPK syndromes-Noonan syndrome, cardio-facio-cutaneous syndrome and LEOPARD syndrome.

SUBMITTER: Hussain MR 

PROVIDER: S-EPMC4486731 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature