A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder.

ABSTRACT: Bipolar disorder (BD) is a significant neuropsychiatric disorder with a lifetime prevalence of ~1%. To identify genetic variants underlying BD genome-wide association studies (GWAS) have been carried out. While many variants of small effect associated with BD have been identified few have yet been confirmed, partly because of the low power of GWAS due to multiple comparisons being made. Complementary mapping studies using murine models have identified genetic variants for behavioral traits linked to BD, often with high power, but these identified regions often contain too many genes for clear identification of candidate genes. In the current study we have aligned human BD GWAS results and mouse linkage studies to help define and evaluate candidate genes linked to BD, seeking to use the pow

SUBMITTER: Ashbrook DG 

PROVIDER: S-EPMC4486840 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature