Molecular characterization of hepatocarcinogenesis using mouse models.

ABSTRACT: Hepatocellular carcinoma (HCC) is a deadly disease, often unnoticed until the late stages, when treatment options become limited. Thus, there is a crucial need to identify biomarkers for early detection of developing HCC, as well as molecular pathways that would be amenable to therapeutic intervention. Although analysis of human HCC tissues and serum components may serve these purposes, inability of early detection also precludes possibilities of identification of biomarkers or pathways that are sequentially perturbed at earlier phases of disease progression. We have therefore explored the option of utilizing mouse models to understand in a systematic and longitudinal manner the molecular pathways that are progressively deregulated by various etiological factors in contributing to HCC form

SUBMITTER: Teoh WW 

PROVIDER: S-EPMC4486853 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature