Single-nucleotide polymorphism of the UMOD promoter is associated with the outcome of chronic kidney disease patients.

ABSTRACT: Uromodulin (UMOD) is the most abundant protein secreted in urine and the mutated form of the UMOD gene is associated with UMOD-associated kidney disease (UAKD). Although UMOD accumulates in the kidney of UAKD patients, it is unclear whether this also occurred in the chronic kidney disease (CKD) patients. Therefore, the association of single-nucleotide polymorphisms (SNPs) in the promoter region of UMOD gene with the kidney survival time of CKD was investigated. The promoter region of the UMOD gene was sequenced for 111 CKD patients. The Kaplan-Meier method was used to identify the disease outcome associated with SNPs in the promoter region of the UMOD gene in CKD patients. The Cox proportional hazard model was used to identify risk factors for the kidney surviva

SUBMITTER: Cui L 

PROVIDER: S-EPMC4487055 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature