The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target.

ABSTRACT:

Background

Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while antibiotic treatment options, the sole counter measures against gonorrhea, are declining due to the remarkable ability of GC to acquire resistance. Evaluating of potential drug targets is essential to provide opportunities for developing antimicrobials with new mechanisms of action. We propose the GC Obg protein, belonging to the Obg/CgtA GTPase subfamily, as a potential target for the developmen

SUBMITTER: Zielke RA 

PROVIDER: S-EPMC4487204 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature