CD4+ gain percentile curves for monitoring response to antiretroviral therapy in HIV-infected adults.

ABSTRACT:

Objectives

We constructed CD4 cell count gain percentile distributions standardized by baseline CD4 cell count and assessed the association between poor CD4 cell count gain and subsequent death and virological failure on antiretroviral therapy (ART).

Design

Secondary analysis of 10 years of clinical data from a cohort of adults initiated on ART at the Themba Lethu clinic in Johannesburg, South Africa.

Methods

The generalized additive model for location, scale and shape was used to construct percentile curves for CD4 cell count gain standardized by baseline CD4 cell count in the first 28 months of ART. Cox proportional models were used to assess the association between lower percentiles (<50th) of CD4 cell count gain, and subsequent death and virological failure.

Re

SUBMITTER: Yotebieng M 

PROVIDER: S-EPMC4487417 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature