Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study.

ABSTRACT:

Background

Cognitive impairment and depression frequently co-occur in late life. There remains a need to better characterize psychosocial risk factors of cognitive decline in older adults with depression. We hypothesized that certain psychosocial factors would be associated with higher risk of cognitive decline in individuals with late-life depression.

Methods

130 individuals aged ≥ 65 years who had achieved remission from a major depressive episode were randomized to donepezil or placebo and then closely followed for two years. Using Cox proportional hazard models, we examined the association between baseline median household income, education level, race, marital status, and social support and cognitive decline over the follow-up.

Results

Lower interpersonal support

SUBMITTER: Rej S 

PROVIDER: S-EPMC4487735 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature