Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study.

ABSTRACT:

Background

Stem-cell-based, tissue engineered transplants might offer new therapeutic options for patients, including children, with failing organs. The reported replacement of an adult airway using stem cells on a biological scaffold with good results at 6 months supports this view. We describe the case of a child who received a stem-cell-based tracheal replacement and report findings after 2 years of follow-up.

Methods

A 12-year-old boy was born with long-segment congenital tracheal stenosis and pulmonary sling. His airway had been maintained by metal stents, but, after failure, a cadaveric donor tracheal scaffold was decellularised. After a short course of granulocyte colony stimulating factor, bone marrow mesenchymal stem cells were retrieved preoperatively and seeded on

SUBMITTER: Elliott MJ 

PROVIDER: S-EPMC4487824 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature