Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures.

ABSTRACT:

Introduction

Non-invasive diffuse optical tomography (DOT) and diffuse correlation spectroscopy (DCS) can detect and characterize breast cancer and predict tumor responses to neoadjuvant chemotherapy, even in patients with radiographically dense breasts. However, the relationship between measured optical parameters and pathological biomarker information needs to be further studied to connect information from optics to traditional clinical cancer biology. Thus we investigate how optically measured physiological parameters in malignant tumors such as oxy-, deoxy-hemoglobin concentration, tissue blood oxygenation, and metabolic rate of oxygen correlate with microscopic histopathological biomarkers from the same malignant tumors, e.g., Ki67 proliferation markers, CD34 stained vasculatu

SUBMITTER: Chung SH 

PROVIDER: S-EPMC4487833 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature