Simplified Citrate Anticoagulation for CRRT Without Calcium Replacement.

ABSTRACT: Since 2012, citrate anticoagulation is the recommended anticoagulation strategy for continuous renal replacement therapy (CRRT). The main drawback using citrate as anticoagulant compared with heparin is the need for calcium replacement and the rigorous control of calcium levels. This study investigated the possibility to achieve anticoagulation while eliminating the need for calcium replacement. This was successfully achieved by including citrate and calcium in all CRRT solutions. Thereby the total calcium concentration was kept constant throughout the extracorporeal circuit, whereas the ionized calcium was kept at low levels enough to avoid clotting. Being a completely new concept, only five patients with acute renal failure were included in a short, prospective, intensely supervised nonr

SUBMITTER: Broman M 

PROVIDER: S-EPMC4487873 | biostudies-literature | 2015 Jul-Aug

REPOSITORIES: biostudies-literature