The Impact of Gene Polymorphisms on the Success of Anticholinergic Treatment in Children with Overactive Bladder.

ABSTRACT:

Aim

To determine the impact of gene polymorphisms on detrusor contraction-relaxation harmony in children with lower urinary tract symptoms (LUTS).

Materials and methods

Toilet trained children older than 5 years of age with LUTS and normal neurological examination underwent videourodynamic study. The control group was composed of age matched children with no voiding complaints. The study group who filled out the voiding dysfunction symptom score before and after the treatment received standard oxybutynin treatment and was reevaluated 1 year after treatment. Genomic DNA was isolated from all patients and subjected to PCR for amplification. Genotyping of ARGHEF10, ROCK2, ADRB3, and CYP3A4 was carried out with Polymerase Chain Reaction- Restriction Fragment Length Polymorphism

SUBMITTER: Gurocak S 

PROVIDER: S-EPMC4488149 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature