Tissue-Specific Evolution of Protein Coding Genes in Human and Mouse.

ABSTRACT: Protein-coding genes evolve at different rates, and the influence of different parameters, from gene size to expression level, has been extensively studied. While in yeast gene expression level is the major causal factor of gene evolutionary rate, the situation is more complex in animals. Here we investigate these relations further, especially taking in account gene expression in different organs as well as indirect correlations between parameters. We used RNA-seq data from two large datasets, covering 22 mouse tissues and 27 human tissues. Over all tissues, evolutionary rate only correlates weakly with levels and breadth of expression. The strongest explanatory factors of purifying selection are GC content, expression in many developmental stages, and expression in brain tissues. While th

SUBMITTER: Kryuchkova-Mostacci N 

PROVIDER: S-EPMC4488272 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature