Successful Working Memory Processes and Cerebellum in an Elderly Sample: A Neuropsychological and fMRI Study.

ABSTRACT:

Background

Imaging studies help to understand the evolution of key cognitive processes related to aging, such as working memory (WM). This study aimed to test three hypotheses in older adults. First, that the brain activation pattern associated to WM processes in elderly during successful low load tasks is located in posterior sensory and associative areas; second, that the prefrontal and parietal cortex and basal ganglia should be more active during high-demand tasks; third, that cerebellar activations are related to high-demand cognitive tasks and have a specific lateralization depending on the condition.

Methods

We used a neuropsychological assessment with functional magnetic resonance imaging and a core N-back paradigm design that was maintained across the combination of

SUBMITTER: Luis EO 

PROVIDER: S-EPMC4488500 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature