Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin.

ABSTRACT: Removal of dead cells in the absence of concomitant immune stimulation is essential for tissue homeostasis. We recently identified an injury-induced protein misfolding event that orchestrates the plasmin-dependent proteolytic degradation of necrotic cells. As impaired clearance of dead cells by the innate immune system predisposes to autoimmunity, we determined whether plasmin could influence endocytosis and immune cell stimulation by dendritic cells - a critical cell that links the innate and adaptive immune systems. We find that plasmin generated on the surface of necrotic cells enhances their phagocytic removal by human monocyte-derived dendritic cells. Plasmin also promoted phagocytosis of protease-resistant microparticles by diverse mouse dendritic cell sub-types both in vitro and in

SUBMITTER: Borg RJ 

PROVIDER: S-EPMC4488505 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature