Molecular Analysis of Mixed Endometrioid and Serous Adenocarcinoma of the Endometrium.

ABSTRACT:

Background

The molecular biology and cellular origins of mixed type endometrial carcinomas (MT-ECs) are poorly understood, and a Type II component of 10 percent or less may confer poorer prognoses.

Methodology/principal findings

We studied 10 cases of MT-EC (containing endometrioid and serous differentiation), 5 pure low-grade endometrioid adenocarcinoma (EAC) and 5 pure uterine serous carcinoma (USC). Endometrioid and serous components of the MT-ECs were macrodissected and the expression of 60 candidate genes compared between MT-EC, pure USC and pure EAC. We found that four genes were differentially expressed when MT-ECs were compared to pure low-grade EAC: CDKN2A (P = 0.006), H19 (P = 0.010), HOMER2 (P = 0.009) and TNNT1 (P = 0.006). Also while we found that even though MT

SUBMITTER: Lawrenson K 

PROVIDER: S-EPMC4488511 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature