Successive Generations in a Rat Model Respond Differently to a Constant Obesogenic Environment.

ABSTRACT: Research has shown that if a mother experiences a transitory perturbation to her environment during pregnancy or lactation, there are transgenerational consequences often involving a disordered metabolic phenotype in first generation offspring with recovery across subsequent generations. In contrast, little is known about the nature of the transgenerational response of offspring when a mother experiences a perturbation that is not transitory but instead persists across generations. Our study, using a rat model, subjected the parental generation to a change in environment and concomitant shift from a grain-based to obesogenic diets to generate an adipose phenotype in first generation offspring emulating a common scenario in human urbanisation and migration. We then investigated whether the

SUBMITTER: Tait AH 

PROVIDER: S-EPMC4488537 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature