MiR-23a impairs bone differentiation in osteosarcoma via down-regulation of GJA1.

ABSTRACT: Osteosarcoma is the most common type of bone cancer in children and adolescents. Impaired differentiation of osteoblast cells is a distinguishing feature of this aggressive disease. As improvements in survival outcomes have largely plateaued, better understanding of the bone differentiation program may provide new treatment approaches. The miRNA cluster miR-23a~27a~24-2, particularly miR-23a, has been shown to interact with genes important for bone development. However, global changes in gene expression associated with functional gain of this cluster have not been fully explored. To better understand the relationship between miR-23a expression and bone cell differentiation, we carried out a large-scale gene expression analysis in HOS cells. Experimental results demonstrate that over-expres

SUBMITTER: Gindin Y 

PROVIDER: S-EPMC4488756 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature