Statin Effects on Aggression: Results from the UCSD Statin Study, a Randomized Control Trial.

ABSTRACT:

Background

Low/ered cholesterol is linked to aggression in some study designs. Cases/series have reported reproducible aggression increases on statins, but statins also bear mechanisms that could reduce aggression. Usual statin effects on aggression have not been characterized.

Methods

1016 adults (692 men, 324 postmenopausal women) underwent double-blind sex-stratified randomization to placebo, simvastatin 20mg, or pravastatin 40mg (6 months). The Overt-Aggression-Scale-Modified-Aggression-Subscale (OASMa) assessed behavioral aggression. A significant sex-statin interaction was deemed to dictate sex-stratified analysis. Exploratory analyses assessed the influence of baseline-aggression, testosterone-change (men), sleep and age.

Results

The sex-statin interaction was

SUBMITTER: Golomb BA 

PROVIDER: S-EPMC4488854 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature