ITRAQ-Based Quantitative Proteomic Analysis of the Initiation of Head Regeneration in Planarians.

ABSTRACT: The planarian Dugesia japonica has amazing ability to regenerate a head from the anterior ends of the amputated stump with maintenance of the original anterior-posterior polarity. Although planarians present an attractive system for molecular investigation of regeneration and research has focused on clarifying the molecular mechanism of regeneration initiation in planarians at transcriptional level, but the initiation mechanism of planarian head regeneration (PHR) remains unclear at the protein level. Here, a global analysis of proteome dynamics during the early stage of PHR was performed using isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomics strategy, and our data are available via ProteomeXchange with identifier PXD002100. The results showed that

SUBMITTER: Geng X 

PROVIDER: S-EPMC4488856 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature