Heat-Denatured Lysozyme Inactivates Murine Norovirus as a Surrogate Human Norovirus.

ABSTRACT: Human norovirus infects humans through the consumption of contaminated food, contact with the excrement or vomit of an infected person, and through airborne droplets that scatter the virus through the air. Being highly infectious and highly viable in the environment, inactivation of the norovirus requires a highly effective inactivating agent. In this study, we have discovered the thermal denaturing capacity of a lysozyme with known antimicrobial activity against gram-positive bacteria, as well as its inactivating effect on murine norovirus. This study is the first report on the norovirus-inactivating effects of a thermally denatured lysozyme. We observed that lysozymes heat-treated for 40 min at 100 °C caused a 4.5 log reduction in infectivity of norovirus. Transmission electron microscop

SUBMITTER: Takahashi H 

PROVIDER: S-EPMC4488868 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature