Capturing coevolutionary signals inrepeat proteins.

ABSTRACT:

Background

The analysis of correlations of amino acid occurrences in globular domains has led to the development of statistical tools that can identify native contacts - portions of the chains that come to close distance in folded structural ensembles. Here we introduce a direct coupling analysis for repeat proteins - natural systems for which the identification of folding domains remains challenging.

Results

We show that the inherent translational symmetry of repeat protein sequences introduces a strong bias in the pair correlations at precisely the length scale of the repeat-unit. Equalizing for this bias in an objective way reveals true co-evolutionary signals from which local native contacts can be identified. Importantly, parameter values obtained for all other interact

SUBMITTER: Espada R 

PROVIDER: S-EPMC4489039 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature