A bioinformatic framework for immune repertoire diversity profiling enables detection of immunological status.

ABSTRACT:

Background

Lymphocyte receptor repertoires are continually shaped throughout the lifetime of an individual in response to environmental and pathogenic exposure. Thus, they may serve as a fingerprint of an individual's ongoing immunological status (e.g., healthy, infected, vaccinated), with far-reaching implications for immunodiagnostics applications. The advent of high-throughput immune repertoire sequencing now enables the interrogation of immune repertoire diversity in an unprecedented and quantitative manner. However, steadily increasing sequencing depth has revealed that immune repertoires vary greatly among individuals in their composition; correspondingly, it has been reported that there are few shared sequences indicative of immunological status ('public clones'). Disconcert

SUBMITTER: Greiff V 

PROVIDER: S-EPMC4489130 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature