The contribution of mammography screening to breast cancer incidence trends in the United States: an updated age-period-cohort model.

ABSTRACT:

Background

The impact of screening mammography on breast cancer incidence is difficult to disentangle from cohort- and age-related effects on incidence.

Methods

We developed an age-period-cohort model of ductal carcinoma in situ (DCIS) and invasive breast cancer incidence in U.S. females using cancer registry data. Five functions were included in the model to estimate stage-specific effects for age, premenopausal birth cohorts, postmenopausal birth cohorts, period (for all years of diagnosis), and a mammography period effect limited to women ages ≥ 40 years after 1982. Incidence with and without the mammography period effect was calculated.

Results

More recent birth cohorts have elevated underlying risk compared with earlier cohorts for both pre- and postmenopausal wo

SUBMITTER: Gangnon RE 

PROVIDER: S-EPMC4489135 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature