AGGRESCAN3D (A3D): server for prediction of aggregation properties of protein structures.

ABSTRACT: Protein aggregation underlies an increasing number of disorders and constitutes a major bottleneck in the development of therapeutic proteins. Our present understanding on the molecular determinants of protein aggregation has crystalized in a series of predictive algorithms to identify aggregation-prone sites. A majority of these methods rely only on sequence. Therefore, they find difficulties to predict the aggregation properties of folded globular proteins, where aggregation-prone sites are often not contiguous in sequence or buried inside the native structure. The AGGRESCAN3D (A3D) server overcomes these limitations by taking into account the protein structure and the experimental aggregation propensity scale from the well-established AGGRESCAN method. Using the A3D server, the identifi

SUBMITTER: Zambrano R 

PROVIDER: S-EPMC4489226 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature