PyDockSAXS: protein-protein complex structure by SAXS and computational docking.

ABSTRACT: Structural characterization of protein-protein interactions at molecular level is essential to understand biological processes and identify new therapeutic opportunities. However, atomic resolution structural techniques cannot keep pace with current advances in interactomics. Low-resolution structural techniques, such as small-angle X-ray scattering (SAXS), can be applied at larger scale, but they miss atomic details. For efficient application to protein-protein complexes, low-resolution information can be combined with theoretical methods that provide energetic description and atomic details of the interactions. Here we present the pyDockSAXS web server (http://life.bsc.es/pid/pydocksaxs) that provides an automatic pipeline for modeling the structure of a protein-protein complex from SAXS

SUBMITTER: Jimenez-Garcia B 

PROVIDER: S-EPMC4489248 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature