SELPHI: correlation-based identification of kinase-associated networks from global phospho-proteomics data sets.

ABSTRACT: While phospho-proteomics studies have shed light on the dynamics of cellular signaling, they mainly describe global effects and rarely explore mechanistic details, such as kinase/substrate relationships. Tools and databases, such as NetworKIN and PhosphoSitePlus, provide valuable regulatory details on signaling networks but rely on prior knowledge. They therefore provide limited information on less studied kinases and fewer unexpected relationships given that better studied signaling events can mask condition- or cell-specific 'network wiring'. SELPHI is a web-based tool providing in-depth analysis of phospho-proteomics data that is intuitive and accessible to non-bioinformatics experts. It uses correlation analysis of phospho-sites to extract kinase/phosphatase and phospho-peptide associa

SUBMITTER: Petsalaki E 

PROVIDER: S-EPMC4489257 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature