NFFinder: an online bioinformatics tool for searching similar transcriptomics experiments in the context of drug repositioning.

ABSTRACT: Drug repositioning, using known drugs for treating conditions different from those the drug was originally designed to treat, is an important drug discovery tool that allows for a faster and cheaper development process by using drugs that are already approved or in an advanced trial stage for another purpose. This is especially relevant for orphan diseases because they affect too few people to make drug research de novo economically viable. In this paper we present NFFinder, a bioinformatics tool for identifying potential useful drugs in the context of orphan diseases. NFFinder uses transcriptomic data to find relationships between drugs, diseases and a phenotype of interest, as well as identifying experts having published on that domain. The application shows in a dashboard a series of gr

SUBMITTER: Setoain J 

PROVIDER: S-EPMC4489258 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature