StemChecker: a web-based tool to discover and explore stemness signatures in gene sets.

ABSTRACT: Stem cells present unique regenerative abilities, offering great potential for treatment of prevalent pathologies such as diabetes, neurodegenerative and heart diseases. Various research groups dedicated significant effort to identify sets of genes-so-called stemness signatures-considered essential to define stem cells. However, their usage has been hindered by the lack of comprehensive resources and easy-to-use tools. For this we developed StemChecker, a novel stemness analysis tool, based on the curation of nearly fifty published stemness signatures defined by gene expression, RNAi screens, Transcription Factor (TF) binding sites, literature reviews and computational approaches. StemChecker allows researchers to explore the presence of stemness signatures in user-defined gene sets, witho

SUBMITTER: Pinto JP 

PROVIDER: S-EPMC4489266 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature