XVis: a web server for the schematic visualization and interpretation of crosslink-derived spatial restraints.

ABSTRACT: The identification of crosslinks by mass spectrometry has recently been established as an integral part of the hybrid structural analysis of protein complexes and networks. The crosslinking analysis determines distance restraints between two covalently linked amino acids which are typically summarized in a table format that precludes the immediate and comprehensive interpretation of the topological data. xVis displays crosslinks in clear schematic representations in form of a circular, bar or network diagram. The interactive graphs indicate the linkage sites and identification scores, depict the spatial proximity of structurally and functionally annotated protein regions and the evolutionary conservation of amino acids and facilitate clustering of proteins into subcomplexes according to th

SUBMITTER: Grimm M 

PROVIDER: S-EPMC4489277 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature