Tinkering signaling pathways by gain and loss of protein isoforms: the case of the EDA pathway regulator EDARADD.

ABSTRACT:

Background

Only a handful of signaling pathways are major actors of development and responsible for both the conservation and the diversification of animal morphologies. To explain this twofold nature, gene duplication and enhancer evolution were predominantly put forth as tinkering mechanisms whereas the evolution of alternative isoforms has been, so far, overlooked. We investigate here the role of gain and loss of isoforms using Edaradd, a gene of the Ecodysplasin pathway, implicated in morphological evolution. A previous study had suggested a scenario of isoform gain and loss with an alternative isoform (A) newly gained in mammals but secondarily lost in mouse lineage.

Results

For a comprehensive view of A and B Edaradd isoforms history during mammal evolution, we obtaine

SUBMITTER: Sadier A 

PROVIDER: S-EPMC4489351 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature