Low Copy Number of the AMY1 Locus Is Associated with Early-Onset Female Obesity in Finland.

ABSTRACT:

Background

The salivary α-amylase locus (AMY1) is located in a highly polymorphic multi allelic copy number variable chromosomal region. A recent report identified an association between AMY1 copy numbers and BMI in common obesity. The present study investigated the relationship between AMY1 copy number, BMI and serum amylase in childhood-onset obesity.

Patients

Sixty-one subjects with a history of childhood-onset obesity (mean age 19.1 years, 54% males) and 71 matched controls (19.8 yrs, 45% males) were included. All anthropometric measures were greater in the obese; their mean BMI was 40 kg/m2 (range 25-62 kg/m2) compared with 23 kg/m2 in the controls (15-32 kg/m2).

Results

Mean AMY1 copy numbers did not differ between the obese and control subjects, but gender diff

SUBMITTER: Viljakainen H 

PROVIDER: S-EPMC4489572 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature