Plasma leptin levels, LEPR Q223R polymorphism and mammographic breast density: a cross-sectional study.

ABSTRACT: Obesity is associated with breast cancer in post-menopausal women, and breast density is a marker of breast cancer risk. Leptin is produced by the adipose tissue, acts through receptors that are polymorphic in nature, and is considered a cancer growth factor. The relationship between body mass index, leptin, leptin receptors and breast density is not well studied. A cross-sectional analysis in 392 post-menopausal healthy women was conducted; participants provided permission to obtain copies of their most recent screening mammogram. Non-fasting plasma leptin levels were determined using a commercially available leptin ELISA kit. Analysis of the Q223R genotypes of the LEPR gene were performed by PCR followed by restriction fragment length polymorphism analysis using DNA extracted from buffy

SUBMITTER: Dallal C 

PROVIDER: S-EPMC4489688 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature