Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.

ABSTRACT:

Background

The prediction of clinical behavior, response to therapy, and outcome of infiltrative glioma is challenging. On the basis of previous studies of tumor biology, we defined five glioma molecular groups with the use of three alterations: mutations in the TERT promoter, mutations in IDH, and codeletion of chromosome arms 1p and 19q (1p/19q codeletion). We tested the hypothesis that within groups based on these features, tumors would have similar clinical variables, acquired somatic alterations, and germline variants.

Methods

We scored tumors as negative or positive for each of these markers in 1087 gliomas and compared acquired alterations and patient characteristics among the five primary molecular groups. Using 11,590 controls, we assessed associations between these

SUBMITTER: Eckel-Passow JE 

PROVIDER: S-EPMC4489704 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature