Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.

ABSTRACT:

Objective

Perineuronal nets (PN) form a specialized extracellular matrix around certain highly active neurons within the central nervous system and may help to stabilize synaptic contacts, promote local ion homeostasis, or play a protective role. Within the ocular motor system, excitatory burst neurons and omnipause neurons are highly active cells that generate rapid eye movements - saccades; both groups of neurons contain the calcium-binding protein parvalbumin and are ensheathed by PN. Experimental lesions of excitatory burst neurons and omnipause neurons cause slowing or complete loss of saccades. Selective palsy of saccades in humans is reported following cardiac surgery, but such cases have shown normal brainstem neuroimaging, with only one clinicopathological study that demon

SUBMITTER: Eggers SD 

PROVIDER: S-EPMC4489868 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature