Associations of Independent IL2RA Gene Variants with Intermediate Uveitis.

ABSTRACT:

Purpose

The genetic background for the concomitance of uveitis and other autoimmune diseases remains elusive. Here the role of two IL2RA gene variants (rs11594656 and rs12722495) was investigated in intermediate uveitis and HLAB27 acute anterior uveitis.

Materials and methods

One hundred fifty-nine patients with HLAB27 acute anterior uveitis, 85 patients with intermediate uveitis, 138 HLAB27 negative controls and 100 HLAB27 positive controls were recruited for this case-control study. Main outcome measures were genotype distribution and allelic frequencies determined by polymerase chain reaction.

Results

The frequencies of carriers of the minor allele at rs11594656 and rs12722495 were significantly different in patients with intermediate uveitis compared to HLAB27 pos

SUBMITTER: Lindner E 

PROVIDER: S-EPMC4489875 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature