Score for neonatal acute physiology-II and neonatal pain predict corticospinal tract development in premature newborns.

ABSTRACT: Premature infants are at risk for adverse motor outcomes, including cerebral palsy and developmental coordination disorder. The purpose of this study was to examine the relationship of antenatal, perinatal, and postnatal risk factors for abnormal development of the corticospinal tract, the major voluntary motor pathway, during the neonatal period. In a prospective cohort study, 126 premature neonates (24-32 weeks' gestational age) underwent serial brain imaging near birth and at term-equivalent age. With diffusion tensor tractography, mean diffusivity and fractional anisotropy of the corticospinal tract were measured to reflect microstructural development. Generalized estimating equation models examined associations of risk factors on corticospinal tract development. The perinatal risk fac

SUBMITTER: Zwicker JG 

PROVIDER: S-EPMC4489879 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature