Ontology highlight
ABSTRACT:
SUBMITTER: Sarioglu AF
PROVIDER: S-EPMC4490017 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Nature methods 20150518 7
Cancer cells metastasize through the bloodstream either as single migratory circulating tumor cells (CTCs) or as multicellular groupings (CTC clusters). Existing technologies for CTC enrichment are designed to isolate single CTCs, and although CTC clusters are detectable in some cases, their true prevalence and significance remain to be determined. Here we developed a microchip technology (the Cluster-Chip) to capture CTC clusters independently of tumor-specific markers from unprocessed blood. C ...[more]