Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation.

ABSTRACT: We present a robot that enables high-content studies of alert adult Drosophila by combining operations including gentle picking; translations and rotations; characterizations of fly phenotypes and behaviors; microdissection; or release. To illustrate, we assessed fly morphology, tracked odor-evoked locomotion, sorted flies by sex, and dissected the cuticle to image neural activity. The robot's tireless capacity for precise manipulations enables a scalable platform for screening flies' complex attributes and behavioral patterns.

SUBMITTER: Savall J 

PROVIDER: S-EPMC4490062 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature