Distinguishing Adolescents With ADHD From Their Unaffected Siblings and Healthy Comparison Subjects by Neural Activation Patterns During Response Inhibition.

ABSTRACT:

Objective

Dysfunctional response inhibition is a key executive function impairment in attention deficit hyperactivity disorder (ADHD). Still, behavioral response inhibition measures do not consistently differentiate affected from unaffected individuals. The authors therefore investigated neural correlates of response inhibition and the familial nature of these neural correlates.

Methods

Functional MRI measurements of neural activation during the stop-signal task and behavioral measures of response inhibition were obtained in adolescents and young adults with ADHD (N=185), their unaffected siblings (N=111), and healthy comparison subjects (N=124).

Results

Stop-signal task reaction times were longer and error rates were higher in participants with ADHD, but not in their

SUBMITTER: van Rooij D 

PROVIDER: S-EPMC4490085 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature