Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing.

ABSTRACT:

Purpose

Mounting evidence supports the clinical significance of gene mutations and immunogenetic features in common mature B-cell malignancies.

Experimental design

We undertook a detailed characterization of the genetic background of splenic marginal zone lymphoma (SMZL), using targeted resequencing and explored potential clinical implications in a multinational cohort of 175 patients with SMZL.

Results

We identified recurrent mutations in TP53 (16%), KLF2 (12%), NOTCH2 (10%), TNFAIP3 (7%), MLL2 (11%), MYD88 (7%), and ARID1A (6%), all genes known to be targeted by somatic mutation in SMZL. KLF2 mutations were early, clonal events, enriched in patients with del(7q) and IGHV1-2*04 B-cell receptor immunoglobulins, and were associated with a short median time to first tre

SUBMITTER: Parry M 

PROVIDER: S-EPMC4490180 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature