Genomic epidemiology of multidrug-resistant Mycobacterium tuberculosis during transcontinental spread.

ABSTRACT: The transcontinental spread of multidrug-resistant (MDR) tuberculosis is poorly characterized in molecular epidemiologic studies. We used genomic sequencing to understand the establishment and dispersion of MDR Mycobacterium tuberculosis within a group of immigrants to the United States. We used a genomic epidemiology approach to study a genotypically matched (by spoligotype, IS6110 restriction fragment length polymorphism, and mycobacterial interspersed repetitive units-variable number of tandem repeat signature) lineage 2/Beijing MDR strain implicated in an outbreak of tuberculosis among refugees in Thailand and consecutive cases within California. All 46 MDR M. tuberculosis genomes from both Thailand and California were highly related, with a median difference of 10 single-nucleotide po

SUBMITTER: Coscolla M 

PROVIDER: S-EPMC4490235 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature