Involvement of bone marrow cells and neuroinflammation in hypertension.

ABSTRACT:

Rationale

Microglial activation in autonomic brain regions is a hallmark of neuroinflammation in neurogenic hypertension. Despite evidence that an impaired sympathetic nerve activity supplying the bone marrow (BM) increases inflammatory cells and decreases angiogenic cells, little is known about the reciprocal impact of BM-derived inflammatory cells on neuroinflammation in hypertension.

Objective

To test the hypothesis that proinflammatory BM cells from hypertensive animals contribute to neuroinflammation and hypertension via a brain-BM interaction.

Methods and results

After BM ablation in spontaneously hypertensive rats, and reconstitution with normotensive Wistar Kyoto rat BM, the resultant chimeric spontaneously hypertensive rats displayed significant reduction in

SUBMITTER: Santisteban MM 

PROVIDER: S-EPMC4490954 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature