Mendelian Randomization Study of Body Mass Index and Colorectal Cancer Risk.

ABSTRACT:

Background

High body mass index (BMI) is consistently linked to increased risk of colorectal cancer for men, whereas the association is less clear for women. As risk estimates from observational studies may be biased and/or confounded, we conducted a Mendelian randomization study to estimate the causal association between BMI and colorectal cancer.

Methods

We used data from 10,226 colorectal cancer cases and 10,286 controls of European ancestry. The Mendelian randomization analysis used a weighted genetic risk score, derived from 77 genome-wide association study-identified variants associated with higher BMI, as an instrumental variable (IV). We compared the IV odds ratio (IV-OR) with the OR obtained using a conventional covariate-adjusted analysis.

Results

Individual

SUBMITTER: Thrift AP 

PROVIDER: S-EPMC4490960 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature