Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination.

ABSTRACT: T cell infiltration into the CNS is a significant underlying pathogenesis in autoimmune inflammatory demyelinating diseases. Several lines of evidence suggest that glutamate dysregulation in the CNS is an important consequence of immune cell infiltration in neuroinflammatory demyelinating diseases; yet, the causal link between inflammation and glutamate dysregulation is not well understood. A major source of glutamate release during oxidative stress is the system Xc(-) transporter; however, this mechanism has not been tested in animal models of autoimmune inflammatory demyelination. We find that pharmacological and genetic inhibition of system Xc(-) attenuates chronic and relapsing-remitting experimental autoimmune encephalomyelitis (EAE). Remarkably, pharmacological blockade of system Xc(

SUBMITTER: Evonuk KS 

PROVIDER: S-EPMC4490999 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature