Ontology highlight
ABSTRACT:
SUBMITTER: Higgins R
PROVIDER: S-EPMC4491043 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20150604 1
Insults to ER homeostasis activate the unfolded protein response (UPR), which elevates protein folding and degradation capacity and attenuates protein synthesis. While a role for ubiquitin in regulating the degradation of misfolded ER-resident proteins is well described, ubiquitin-dependent regulation of translational reprogramming during the UPR remains uncharacterized. Using global quantitative ubiquitin proteomics, we identify evolutionarily conserved, site-specific regulatory ubiquitylation ...[more]