Susceptibility to male infertility: replication study in Japanese men looking for an association with four GWAS-derived loci identified in European men.

ABSTRACT:

Purpose

A previous genome-wide association study in European men identified four single nucleotide polymorphism (SNP) loci associated with male infertility. Our aim was to replicate, if possible, the association of these SNPs with Japanese male infertility.

Methods

We genotyped four SNPs (rs5911500, rs10246939, rs2059807, and rs11204546) in 517 Japanese patients with male infertility and 369 fertile controls using SNP-specific real-time polymerase chain reaction TaqMan assays. Subsequently, we divided patients with male infertility into azoospermia (n = 417) and oligospermia subgroups (n = 70).

Results

The four SNPs previously identified in European men showed no significant association with collective male infertility in our Japanese cohort. However, allele frequency

SUBMITTER: Chihara M 

PROVIDER: S-EPMC4491079 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature