Refined analysis of the Campylobacter jejuni iron-dependent/independent Fur- and PerR-transcriptomes.

ABSTRACT:

Background

The genome of Campylobacter jejuni contains two iron activated Fur-family transcriptional regulators, CjFur and CjPerR, which are primarily responsible for regulating iron homeostasis and oxidative stress respectively. Both transcriptional regulators have been previously implicated in regulating diverse functions beyond their primary roles in C. jejuni. To further characterize their regulatory networks, RNA-seq was used to define the transcriptional profiles of C. jejuni NCTC11168 wild type, Δfur, ΔperR and ΔfurΔperR isogenic deletion mutants under both iron-replete and iron-limited conditions.

Results

It was found that 202 genes were differentially expressed in at least one mutant under iron-replete conditions and 331 genes were differentially expressed in at lea

SUBMITTER: Butcher J 

PROVIDER: S-EPMC4491227 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature