An Evidence-Based Review of Alternating Electric Fields Therapy for Malignant Gliomas.

ABSTRACT:

Opinion statement

Glioblastoma is a deadly disease and even aggressive neurosurgical resection followed by radiation and chemotherapy only extends patient survival to a median of 1.5 years. The challenge in treating this type of tumor stems from the rapid proliferation of the malignant glioma cells, the diffuse infiltrative nature of the disease, multiple activated signal transduction pathways within the tumor, development of resistant clones during treatment, the blood brain barrier that limits the delivery of drugs into the central nervous system, and the sensitivity of the brain to treatment effect. Therefore, new therapies that possess a unique mechanism of action are needed to treat this tumor. Recently, alternating electric fields, also known as tumor treating fields (TTField

SUBMITTER: Wong ET 

PROVIDER: S-EPMC4491358 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature