Statistical dictionaries for hypothetical in silico model of the early-stage intermediate in protein folding.

ABSTRACT: The polypeptide chain folding process appears to be a multi-stage phenomenon. The scientific community has recently devoted much attention to early stages of this process, with numerous attempts at simulating them--either experimentally or in silico. This paper presents a comparative analysis of the predicted and observed results of folding simulations. The proposed technique, based on statistical dictionaries, yields a global accuracy of 57%--a marked improvement over older approaches (with an accuracy of approximately 46%).

SUBMITTER: Kalinowska B 

PROVIDER: S-EPMC4491364 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature